The 12 Hallmarks of Aging
Aging is a natural biological process involving changes in body structures and functions over time. Scientific research, including the linked review, has described twelve mechanisms, known as the “hallmarks of aging,” that contribute to these changes. Learning about these hallmarks can provide general information on ways to support healthy aging through lifestyle choices and nutrition. This article offers an overview of each hallmark and general wellness strategies, including how certain natural ingredients found in dietary supplements like Longevity Synergy may support normal body functions based on available research.†
1. Genomic Instability
What It Is:
Genomic instability refers to the accumulation of changes in DNA over time, which can affect normal cellular processes.
Role in Aging:
As DNA changes build up, they may influence cell health and tissue maintenance.
General Wellness Strategies:
Antioxidant-Rich Foods: Eating foods high in antioxidants may support the body's natural defenses against oxidative stress.
Regular Exercise: Physical activity can promote overall cellular health.
Ingredient Spotlight: Ingredients like green tea (EGCG), rosemary (carnosic acid and carnosol), resveratrol, and luteolin in Longevity Synergy are antioxidants that may help support the body's normal response to oxidative stress and maintain cell integrity through pathways such as Nrf2, based on available research.†
For informational purposes, studies suggest:
- Green tea (EGCG) may support antioxidant responses in cellular models: Modulation of Nrf2 by EGCG
- Rosemary compounds (carnosic acid, carnosol) are associated with Nrf2 activation in preclinical studies: Rosemary Reverses Oxidative Stress through Nrf2
- Luteolin may enhance antioxidant defenses in muscle cells: Oxidative Stress Suppresion by Luteolin
2. Telomere Attrition
What It Is:
Telomeres are protective structures at the ends of chromosomes that naturally shorten with cell divisions.
Role in Aging:
Shortening telomeres can affect cell replication and normal function.
General Wellness Strategies:
Lifestyle Habits: Managing stress and maintaining a balanced diet may support overall cellular wellness.
Physical Activity: Exercise is associated with general health benefits.
Ingredient Spotlight: Ingredients like Gotu Kola, resveratrol, and ursolic acid in Longevity Synergy may contribute to normal cellular function through pathways such as sirtuins and antioxidant support, based on available research.†
For informational purposes, studies suggest:
- Gotu Kola may support telomerase activity in cellular models: Potential Antiaging Effects of Centella asiatica
- Resveratrol is associated with SIRT1 activation in preclinical studies: Mechanism of SIRT1 Activation by Resveratrol
- Ursolic acid may regulate proteins like SIRT1 in animal models: Ursolic Acid Activates SIRT1
3. Epigenetic Alterations
What It Is:
Epigenetic changes involve modifications that influence gene expression without changing the DNA sequence itself, often affected by environment and lifestyle.
Role in Aging:
These alterations can impact how genes function in maintaining body structures.
General Wellness Strategies:
Nutritious Diet: Foods rich in polyphenols may support normal gene expression processes.
Mindfulness Practices: Stress reduction techniques can promote overall well-being.
Ingredient Spotlight: Ingredients like green tea (EGCG), resveratrol, and ginger (gingerols) in Longevity Synergy may help maintain normal epigenetic functions through pathways like sirtuins as part of a healthy lifestyle, based on available research.†
For informational purposes, studies suggest:
- Green tea (EGCG) may influence histone acetylation in cellular models: EGCG Alters Histone Acetylation
- Resveratrol is associated with SIRT1 activation in preclinical studies: SIRT1, AMPK, Beneficial Effects of Resveratrol
- Ginger (gingerols) may support antioxidant responses via SIRT1 in animal models: Ginger Controls mTOR Through AMPK
4. Loss of Proteostasis
What It Is:
Proteostasis involves the body's processes for maintaining protein balance, folding, and turnover in cells.
Role in Aging:
Disruptions can lead to imbalances affecting cellular health.
General Wellness Strategies:
Balanced Protein Intake: High-quality proteins from food support normal protein maintenance.
Exercise: Activity can enhance overall protein handling in the body.
Ingredient Spotlight: Ingredients like rosemary (carnosic acid and carnosol), resveratrol, and ursolic acid in Longevity Synergy provide antioxidant support that may contribute to general cellular wellness through pathways like Nrf2, mTOR, AMPK, and sirtuins, based on available research.†
For informational purposes, studies suggest:
- Rosemary compounds (carnosic acid, carnosol) may induce cellular processes via Nrf2 in neuronal models: Carnosol and Proteostasis
- Resveratrol promotes autophagy-related pathways via SIRT1 in preclinical studies: Resveratrol, SIRT1, and Autophagy
- Ursolic acid may enhance protein regulation via SIRT1 in aging models: Ursolic Acid, SIRT1, and Mitochondria
5. Intracellular Accumulation of Waste Products (Disabled Autophagy)
What It Is:
Cells naturally recycle components through autophagy, but this process can slow, leading to buildup of cellular material.
Role in Aging:
This may affect normal cell cleaning and function.
General Wellness Strategies:
Healthy Eating Patterns: Caloric balance and exercise may support natural cellular recycling.
Hydration: Staying hydrated aids overall body functions.
Ingredient Spotlight: Ingredients like green tea (EGCG), ginger (gingerols), ursolic acid, and resveratrol in Longevity Synergy are associated with supporting normal cellular processes through pathways like AMPK and mTOR in general health contexts, based on available research.†
For informational purposes, studies suggest:
- Green tea (EGCG) may balance energy pathways like mTOR-AMPK in cellular models: Green Tea Regulates Autophagy
- Ginger (gingerols) may enhance cellular responses in preclinical models: Ginger Promotes Autophagy
- Ursolic acid may induce autophagy in cell studies: Ursolic Acid induces Apoptosis and Autophagy
- Resveratrol may induce cellular processes via AMPK in aging models: Resveratrol, Autophagy, AMPK, mTOR
6. Deregulated Nutrient Sensing
What It Is:
Nutrient-sensing pathways, like mTOR and AMPK, help cells respond to energy and nutrient levels.
Role in Aging:
Changes can influence metabolic balance.
General Wellness Strategies:
Balanced Nutrition: A nutrient-dense diet supports normal metabolic functions.
Caloric Awareness: Mindful eating habits promote wellness.
Ingredient Spotlight: Ingredients like ursolic acid, resveratrol, green tea (EGCG), and ginger (gingerols) in Longevity Synergy may support normal nutrient-sensing pathways like mTOR and AMPK as part of a dietary routine, based on available research.†
For informational purposes, studies suggest:
- Ursolic acid may regulate mTOR and AMPK in muscle models: Ursolic Acid Mechanisms of Action
- Resveratrol may activate AMPK in metabolic studies: Antiaging Mechanisms of Resveratrol
- Green tea (EGCG) may modulate AMPK-mTOR in cellular research: EGCG mTOR-AMPK balance
- Ginger (gingerols) may support AMPK activation in adipocyte models: Ginger Reduces Lipid Accumulation
7. Mitochondrial Dysfunction
What It Is:
Mitochondria produce energy in cells, and their efficiency can vary over time.
Role in Aging:
Reduced efficiency may impact energy levels and cellular health.
General Wellness Strategies:
Exercise: Activity supports mitochondrial health.
Nutrient-Rich Foods: Antioxidants and omega-3s contribute to energy production.
Ingredient Spotlight: Ingredients like rosemary (carnosic acid and carnosol), resveratrol, ursolic acid, and ginger (gingerols) in Longevity Synergy may help support the body's natural protection of mitochondrial function through pathways like Nrf2 and AMPK, based on available research.†
For informational purposes, studies suggest:
- Rosemary compounds (carnosic acid, carnosol) may activate Nrf2 in neuronal models: Therapeutic Effects of Rosemary
- Resveratrol may boost biogenesis via AMPK/SIRT1 in preclinical studies: Resveratrol and Mitochondrial Biogenesis
- Ursolic acid may improve mitochondrial biogenesis through AMPK in muscle research: Ursolic Acid Induces Mitochondrial Biogenesis
- Ginger (gingerols) may support AMPK in cellular contexts: Mitochondrial Biogenesis and Ginger via AMPK-PGC1a
8. Cellular Senescence
What It Is:
Cellular senescence is a state where cells stop dividing but remain active, influenced by stress factors.
Role in Aging:
Accumulation can affect tissue environment and inflammation responses.
General Wellness Strategies:
Healthy Diet and Exercise: Fruits, vegetables, and activity support normal cell cycles.
Ingredient Spotlight: Ingredients like isoquercetin, luteolin, resveratrol, and ginger (gingerols) in Longevity Synergy offer general support for a balanced cellular environment through pathways like Nrf2 and AMPK, based on available research.†
For informational purposes, studies suggest:
- Isoquercetin may reduce cellular stress in tissue models: Isoquercetin Induces Apoptosis and Autophagy
- Luteolin may inhibit inflammatory responses via Nrf2 in gastric studies: Luteolin Nrf2 Gastric Protection
- Resveratrol may ameliorate responses via AMPK in endothelial cells: Resveratrol , AMPK and Endothelial Inflammation
- Ginger (gingerols) may provide anti-inflammatory support in models: Gingerols Prevents Cellular Senescene in Human Myoblast Cells
9. Stem Cell Exhaustion
What It Is:
Stem cells help with tissue repair, and their activity can decline naturally.
Role in Aging:
This may reduce the body's normal regeneration processes.
General Wellness Strategies:
Exercise and Nutrition: These support overall stem cell health.
Ingredient Spotlight: Ingredients like Gotu Kola, resveratrol, and ursolic acid in Longevity Synergy may provide general antioxidant and wellness support for cellular health through pathways like sirtuins and Wnt/β-catenin, based on available research.†
For informational purposes, studies suggest:
- Gotu Kola may enhance neural responses in oxidative stress targeted stem cell therapies in cellular models: Centella asiatica as a Potential Adjunct in Stem Cell Therapies
- Resveratrol may exert multiple effects on stem cell responses in pre-clinical trials: Multiple Effects of Resveratrol on Stem Cells
- Ursolic acid may aid in regenerating muscle: Ursolic Acid Promotes Skeletal Muscle Rejuvination
10. Altered Intercellular Communication
What It Is:
Cells communicate via signals, and changes can affect coordination.
Role in Aging:
Disruptions may influence inflammation and tissue balance.
General Wellness Strategies:
Anti-Inflammatory Foods: Omega-3s and produce help maintain normal signaling.
Stress Reduction: Meditation supports well-being.
Ingredient Spotlight: Ingredients like luteolin, ginger (gingerols), and isoquercetin in Longevity Synergy may contribute to normal inflammation responses and support general cellular communication through pathways like AMPK and NF-κB, based on available research.†
For informational purposes, studies suggest:
- Luteolin may modulate signaling to support balance in cellular models: Luteloin and microRNA Signaling Pathways
- Ginger (gingerols) may inhibit responses via AMPK in interaction studies: Effects of Ginger on the Hallmarks of Aging
- Isoquercetin may lower inflammatory factors in animal studies: Isoquercetin Improves Inflammatory Response in Rats
11. Chronic Inflammation
What It Is:
Chronic inflammation is an ongoing low-level response in the body.
Role in Aging:
It can affect overall health and tissue function.
General Wellness Strategies:
Diet and Stress Management: Anti-inflammatory foods and yoga promote balance.
Ingredient Spotlight: Ingredients like luteolin, ginger (gingerols), isoquercetin, and rosemary (carnosic acid) in Longevity Synergy are natural compounds that may support normal inflammatory processes through pathways like Nrf2 and AMPK, based on available research.†
For informational purposes, studies suggest:
- Luteolin may upregulate Nrf2 in oxidative stress models: Luteolin Inhibits Inflammation and Activates Nrf2
- Ginger (gingerols) may suppress responses like NF-κB via Nrf2 in cellular studies: Ginger and Inflammatory Diseases
- Isoquercetin may attenuate factors in vascular models: Preventive Vascular Effects of Quercetin
- Rosemary (carnosic acid) may activate Nrf2 in neuroprotective research: Neuroprotective Benefits of Rosmarius officinalis
12. Dysbiosis
What It Is:
Dysbiosis is an imbalance in the body's microbial communities, especially in the gut.
Role in Aging:
It may influence digestion, immunity, and general health.
General Wellness Strategies:
Fiber-Rich Diet: Whole foods, probiotics, and exercise support gut balance.
Stress Reduction: Mindfulness aids microbiome health.
Ingredient Spotlight: Ingredients like green tea (EGCG), ginger (gingerols), and isoquercetin in Longevity Synergy are associated with supporting normal gut health and microbiome balance through pathways like Nrf2 in research.†
For informational purposes, studies suggest:
- Green tea (EGCG) may promote microbial balance in human clinical trials: Green Tea and Gut Microbiota
- Ginger (gingerols) may aid microbiome responses in health studies: Gut Microbiota and Ginger
- Isoquercetin may regulate microbiota in animal models: Isoquercetin and Inulin Modulate Gut Microbiome
Summary
The ingredients in Longevity Synergy, such as Gotu Kola, green tea (EGCG), rosemary (carnosic acid and carnosol), ginger (gingerols), isoquercetin, luteolin, ursolic acid, and resveratrol, may support normal body functions through various pathways like Nrf2 (antioxidant response), mTOR/AMPK (energy balance and metabolism), and sirtuins (cellular regulation), based on available preclinical research.†
Effects can vary by individual factors such as dose and context, and additional human studies are ongoing. This information is for educational purposes and highlights potential areas of interest in supporting overall vitality through nutrition and lifestyle.
Important Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult a healthcare professional before starting any supplement making changes to your diet or routine.